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NIBR189

CAS No. 1599432-08-2

NIBR189( —— )

Catalog No. M20651 CAS No. 1599432-08-2

NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor ?(IC50 of 11 and 15 nM for human and mouse EBI2 receptors respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NIBR189
  • Note
    Research use only, not for human use.
  • Brief Description
    NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor ?(IC50 of 11 and 15 nM for human and mouse EBI2 receptors respectively).
  • Description
    NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor ?(IC50 of 11 and 15 nM for human and mouse EBI2 receptors respectively).
  • In Vitro
    NIBR189 (0-1 μM; 3 h) blocks migration of U937 cells.NIBR189 (0-10 μM) blocks oxysterol-dependent activation with an IC50 value of 9 nM. Cell Migration Assay Cell Line:U937 cell lines Concentration:0-1 μM Incubation Time:3 hours Result:Blocked the direct migration of U937 cells with an IC50 value of 0.3 nM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    GPR183
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1599432-08-2
  • Formula Weight
    429.31
  • Molecular Formula
    C21H21BrN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:47 mg/mL (109.48 mM)
  • SMILES
    COc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)\C=C\c1ccc(Br)cc1
  • Chemical Name
    (E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gessier F Preuss I Yin H et al. Identification and Characterization of Small Molecule Modulators of the Epstein–Barr Virus-Induced Gene 2 (EBI2) Receptor[J]. Journal of Medicinal Chemistry 2014 57(8):3358-3368.
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