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Home - Products - Chromatin/Epigenetic - COX - NCX-4016

NCX-4016

CAS No. 175033-36-0

NCX-4016( Nitroaspirin | NO-Aspirin )

Catalog No. M12651 CAS No. 175033-36-0

NCX-4016 (Nitroaspirin;NO-Aspirin 1) is a nitroderivative of aspirin that combines cyclooxygenase inhibitor with an NO donor, directly and irreversiblely inhibits COX-1.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    NCX-4016
  • Note
    Research use only, not for human use.
  • Brief Description
    NCX-4016 (Nitroaspirin;NO-Aspirin 1) is a nitroderivative of aspirin that combines cyclooxygenase inhibitor with an NO donor, directly and irreversiblely inhibits COX-1.
  • Description
    NCX-4016 (Nitroaspirin;NO-Aspirin 1) is a nitroderivative of aspirin that combines cyclooxygenase inhibitor with an NO donor, directly and irreversiblely inhibits COX-1; suppresses platelet activation, platelet aggregation and thromboxane A2 production, reduces infarct size caused by myocardial ischemia-reperfusion in the anesthetized rat.Diabetes Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Nitroaspirin | NO-Aspirin
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    COX
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    175033-36-0
  • Formula Weight
    331.28
  • Molecular Formula
    C16H13NO7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(OC1=CC=CC=C1CO[N+]([O-])=O)C2=CC=CC=C2OC(C)=O
  • Chemical Name
    2-(Acetyloxy)-benzoic acid 3-[(nitrooxy)methyl]phenyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Corazzi T, et al. J Pharmacol Exp Ther. 2005 Dec;315(3):1331-7. 2. Rossoni G, et al. J Pharmacol Exp Ther. 2001 Apr;297(1):380-7. 3. Lechi C, et al. Thromb Haemost. 1996 Nov;76(5):791-8.
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