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Home - Products - Chromatin/Epigenetic - Histone Demethylase - NCD-38

NCD-38

CAS No. 2078047-42-2

NCD-38( NCD38 | NCD 38 )

Catalog No. M13229 CAS No. 2078047-42-2

NCD-38 is a novel potent, selective LSD1 inhibitor with IC50 of 0.59 uM, exerts highly selective inhibitory activity on LSD1 but no other enzymes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NCD-38
  • Note
    Research use only, not for human use.
  • Brief Description
    NCD-38 is a novel potent, selective LSD1 inhibitor with IC50 of 0.59 uM, exerts highly selective inhibitory activity on LSD1 but no other enzymes.
  • Description
    NCD-38 is a novel potent, selective LSD1 inhibitor with IC50 of 0.59 uM, exerts highly selective inhibitory activity on LSD1 but no other enzymes, such as MAO (IC50>100 uM); inhibits the growth of MLL-AF9 leukemia as well as erythroleukemia, megakaryoblastic leukemia and myelodysplastic syndromes (MDSs) overt leukemia cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NCD38 | NCD 38
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    Histone Demethylase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2078047-42-2
  • Formula Weight
    680.165
  • Molecular Formula
    C37H37ClF3N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N[C@H](C(NCC3=CC=CC(Cl)=C3)=O)CCCCN[C@H]4[C@H](C5=CC=CC=C5)C4
  • Chemical Name
    [1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-[[[(3-chlorophenyl)methyl]amino]carbonyl]-5-[[(1R,2S)-2-phenylcyclopropyl]amino]pentyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Miyamura S, et al. Org Biomol Chem. 2016 Sep 28;14(36):8576-85. 2. Sugino N, et al. Leukemia. 2017 Nov;31(11):2303-2314. 3. Ogasawara D, et al. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8620-4.
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