NAP( ——— )

Catalog No. M41874 CAS No. 211439-12-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

NAP
Note

Research use only, not for human use.
Brief Description

Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic.Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity.
Description

Davunetide is an eight amino acid peptide (NAPVSIPQ) with potent neuroprotection in vitro and in vivo. Davunetide has been shown to enhance functional daily behaviors in schizophrenia patients and to increase memory scores in patients suffering from amnestic mild cognitive impairment.
In Vitro

———
In Vivo

Animal Model:Male Sprague-Dawley rats (Induced by an i.p. streptozotocin (STZ) injection) Dosage:2 μg/kg Administration:Intranasally beginning on the day following the STZ injection and were given daily, 5 days a week, for 16 weeks Result:Impaired spatial memory of the diabetic rats was observed in the water maze by attenuated learning curve and worsened performance in the probe memory test. Davunetide treatment significantly improved both measurements.
Synonyms

———
Pathway

Others
Target

Other Targets
Recptor

———
Research Area

———
Indication

———

CAS Number

211439-12-2
Formula Weight

824.94
Molecular Formula

C36H60N10O12
Purity

>98% (HPLC)
Solubility

DMSO : 125 mg/mL (151.53 mM; ultraphonic; ) H2O : 100 mg/mL (121.22 mM; ultraphonic)
SMILES

———
Chemical Name

——