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Mevociclib

CAS No. 1816989-16-8

Mevociclib( SY-1365 )

Catalog No. M26471 CAS No. 1816989-16-8

Mevociclib is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Mevociclib
  • Note
    Research use only, not for human use.
  • Brief Description
    Mevociclib is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.
  • Description
    Mevociclib is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Mice, HCC70 xenograft model Dosage:20 mg/kg Administration:Intravenous injection, twice weekly, for 35 days Result:Inhibited tumor volume in vivo.
  • Synonyms
    SY-1365
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    Akt| caspase-3| JNK1| p44/42 MAPK| RhoGDI
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1816989-16-8
  • Formula Weight
    587.13
  • Molecular Formula
    C31H35ClN8O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (212.90 mM)
  • SMILES
    CN(C)C\C=C\C(=O)Nc1ccc(nc1)C(=O)N[C@@]1(C)CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kohno K, Ohashi E, et al. Anti-inflammatory effects of adenosine N1-oxide. J Inflamm (Lond). 2015 Jan 20;12(1):2.
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