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Mestranol
CAS No. 72-33-3
Mestranol( EE 3-ME | Ethynyl Estradiol 3-methyl ether | NSC 84032 | SC-475 | Δ-MVE )
Catalog No. M15769 CAS No. 72-33-3
Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 32 | In Stock |
|
| 100MG | 47 | In Stock |
|
| 200MG | 65 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMestranol
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NoteResearch use only, not for human use.
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Brief DescriptionMestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.
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DescriptionMestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives. It is a biologically inactive prodrug of ethinylestradiol to which it is demethylated in the liver with a conversion efficiency of 70%.(In Vitro):Mestranol is a low potency synthetic estrogen that has been shown to be much more stable than 17β-Estradiol(HY-B0141) in hepatoma cell culture.Mestranol (10 μM; 6 days) stimulates the growth of ERpositive MCF-7 WS8 cells up to 250% of control levels, growth stimulation could be partially reversed by tamoxifen.However, in Hep G2 hepatoma cells, Mestranol (10 μM; 6 days) inhibits the growth of Hep 3B cells by 40% compared to control cells. Mestranol alone or cotreatment with tamoxifen both can inhibit cell growth. And cotreatment exhibits an additive effect with tamoxifen on growth inhibition.
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In VitroMestranol is a low potency synthetic estrogen that has been shown to be much more stable than 17β-Estradiol(HY-B0141) in hepatoma cell culture.Mestranol (10 μM; 6 days) stimulates the growth ofERpositive MCF-7 WS8 cells up to 250% of control levels, growth stimulation could be partially reversed by tamoxifen.However, in Hep G2 hepatoma cells, Mestranol (10 μM; 6 days) inhibits the growth of Hep 3B cells by 40% compared to control cells. Mestranol alone or cotreatment with tamoxifen both can inhibit cell growth. And cotreatment exhibits an additive effect with tamoxifen on growth inhibition.
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In Vivo——
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SynonymsEE 3-ME | Ethynyl Estradiol 3-methyl ether | NSC 84032 | SC-475 | Δ-MVE
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorER
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Research AreaEndocrinology
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Indication——
Chemical Information
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CAS Number72-33-3
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Formula Weight310.43
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Molecular FormulaC21H26O2
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Purity>98% (HPLC)
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SolubilityEthanol: 25 mg/mL (80.53 mM); DMSO: 15 mg/mL (48.32 mM)
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SMILESCC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)OC
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Chemical Name17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.IARC Monogr Eval Carcinog Risk Chem Hum. 1979 Dec;21:257-78.
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