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Mepazine
CAS No. 60-89-9
Mepazine( Pecazine )
Catalog No. M26752 CAS No. 60-89-9
Mepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | Get Quote |
|
| 10MG | 50 | Get Quote |
|
| 25MG | 84 | Get Quote |
|
| 50MG | 129 | Get Quote |
|
| 100MG | 178 | Get Quote |
|
| 200MG | 281 | Get Quote |
|
| 500MG | 473 | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameMepazine
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NoteResearch use only, not for human use.
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Brief DescriptionMepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM.
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DescriptionMepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability.(In Vitro):Mepazine (5, 10, and 20 μM) decreases cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.(In Vivo):In female NSG mice with a murine DLBCL xenogeneic tumor model, Mepazine (16 mg/kg; i.p.) interferes with the growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10. Mepazine strongly impairs the expansion of OCI-Ly10 with daily administration.
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In VitroMepazine (5-20 μM; 4 days) causes a decrease of cell viability in the activated B cell subtype of diffuse large B cell lymphoma (ABCDLBCL) cells, without significantly affecting GCB-DLBCL cells. Cell Viability Assay Cell Line:ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4)Concentration:5, 10, and 20 μM Incubation Time:4 days Result:Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.
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In VivoMepazine (16 mg/kg; intraperitoneal administration) interferes with growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10 in NOD/scid IL-2Rgnull (NSG) mice with a murine DLBCL xenogeneic tumor model. Daily administration of Mepazine strongly impairs the expansion of the ABC-DLBCL cell line OCI-Ly10. Animal Model:6- to 8-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice with a murine DLBCL xenogeneic tumor modelDosage:400 μg per animal (25 g), corresponding to approximately 16 mg/kg. Administration:Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application Result:Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.
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SynonymsPecazine
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PathwayApoptosis
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TargetApoptosis
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RecptorAndrogen Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number60-89-9
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Formula Weight310.46
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Molecular FormulaC19H22N2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (322.10 mM)
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SMILESCN1CCCC(CN2c3ccccc3Sc3ccccc23)C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Toure BAKARY-BARRY, et al. Indole compounds as androgen receptor modulators.WO2022020342
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