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Manool

CAS No. 596-85-0

Manool( —— )

Catalog No. M37189 CAS No. 596-85-0

Manool, a diterpene from Salvia miltiorrhiza, showed antitumor activity in a mouse melanoma model.Manool caused cell cycle arrest in the G(2)/M phase of cancer cells, reducing the prevention of chromosomal damage and precancerous lesions.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Manool
  • Note
    Research use only, not for human use.
  • Brief Description
    Manool, a diterpene from Salvia miltiorrhiza, showed antitumor activity in a mouse melanoma model.Manool caused cell cycle arrest in the G(2)/M phase of cancer cells, reducing the prevention of chromosomal damage and precancerous lesions.
  • Description
    Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle.
  • In Vitro
    Manool exhibits higher cytotoxic activity against HeLa (IC50=6.7 μg/mL) and U343 (IC50=6.7 μg/mL) cells.Manool exhibits a protective effect against chromosome damage induced by MMS in HepG2 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    596-85-0
  • Formula Weight
    290.48
  • Molecular Formula
    C20H34O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (344.26 mM; Ultrasonic )
  • SMILES
    C[C@@]12[C@](C(C)(C)CCC1)(CCC(=C)[C@@H]2CC[C@@](C=C)(C)O)[H]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. de Oliveira PF, et al. Manool, a Salvia officinalis diterpene, induces selective cytotoxicity in cancer cells. Cytotechnology. 2016;68(5):2139-2143.?
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