Cart
sales@molnova.com
Macozinone
CAS No. 1377239-83-2
Macozinone( PBTZ169 | PBTZ-169 )
Catalog No. M11559 CAS No. 1377239-83-2
Macozinone (PBTZ-169, PBTZ169)?is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 57 | In Stock |
|
| 5MG | 102 | In Stock |
|
| 10MG | 162 | In Stock |
|
| 25MG | 324 | In Stock |
|
| 50MG | 502 | In Stock |
|
| 100MG | 718 | In Stock |
|
| 500MG | 1431 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMacozinone
-
NoteResearch use only, not for human use.
-
Brief DescriptionMacozinone (PBTZ-169, PBTZ169)?is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
-
DescriptionMacozinone (PBTZ-169, PBTZ169)?is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro; PBTZ169 is less cytotoxic than BTZ043 and shows significantly better efficacy at lower concentrations in the murine model of chronic TB, inhibits DprE1 more efficiently than BTZ043.Bacterial Infection Phase 2 Clinical(In Vitro):Macozinone (PBTZ169) is highly potent against M. tuberculosis in vitro, ex vivo, and in vivo.
-
In Vitro——
-
In Vivo——
-
SynonymsPBTZ169 | PBTZ-169
-
PathwayGPCR/G Protein
-
TargetAntibacterial
-
RecptorDprE1
-
Research AreaInfection
-
IndicationBacterial Infection
Chemical Information
-
CAS Number1377239-83-2
-
Formula Weight456.484
-
Molecular FormulaC20H23F3N4O3S
-
Purity>98% (HPLC)
-
SolubilityDMSO: 6.4 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
-
SMILESO=C1N=C(N2CCN(CC3CCCCC3)CC2)SC4=C([N+]([O-])=O)C=C(C(F)(F)F)C=C14
-
Chemical Name2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Makarov V, et al. EMBO Mol Med. 2014 Mar;6(3):372-83.
2. Makarov V, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4446-52.
3. González-Martínez NA, et al. PLoS Negl Trop Dis. 2015 Oct 16;9(10):e0004022.
4. Lechartier B, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4457-63.
molnova catalog
related products
-
Framycetin
An aminoglycoside antibiotic; selectively inhibits production of the mature miRNA, boosts a downstream protein, and inhibits invasion in HCC cell lines.
-
WCK-5153
WCK-5153 is an enhancer of β-Lactamase and an inhibitor of PBP2 with antimicrobial activities against Pseudomonas aeruginosa.
-
2,6-Dichlorodiphenyl...
2,6-Dichlorodiphenylamine shows activity against Candida albicans infections. 2,6-Dichlorodiphenylamine elevated the MIC by 4-fold of diclofenac sodium (DFNa).
