MX106( MX 106 )

Catalog No. M13467 CAS No. 2170836-81-2

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Product Name

MX106
Note

Research use only, not for human use.
Brief Description

MX106 is a novel potent survivin inhibitor, effectively suppresses MDA-MB-231 cells proliferation with IC50 of 2.2 uM.
Description

MX106 is a novel potent survivin inhibitor, effectively suppresses MDA-MB-231 cells proliferation with IC50 of 2.2 uM; significantly enhances the tumoricidal efficacy of doxorubicin in TNBC cells, induces degradation of XIAP and/or cIAP1, which inhibited NF-κB activation by genotoxic agents.
In Vitro

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In Vivo

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Synonyms

MX 106
Pathway

Apoptosis
Target

IAP
Recptor

IAP
Research Area

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Indication

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CAS Number

2170836-81-2
Formula Weight

390.527
Molecular Formula

C25H30N2O2
Purity

>98% (HPLC)
Solubility

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SMILES

OC1=C2N=CC=CC2=C(COCC3=CC=C(C(C)C)C=C3)C=C1CN4CCCC4
Chemical Name

5-(((4-isopropylbenzyl)oxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol

1. Wang W, et al. J Pharmacol Exp Ther. 2018 May 7. pii: jpet.118.249151.

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