Cart
sales@molnova.com
MS645
CAS No. 2250091-96-2
MS645( —— )
Catalog No. M26309 CAS No. 2250091-96-2
MS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 437 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMS645
-
NoteResearch use only, not for human use.
-
Brief DescriptionMS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.
-
DescriptionMS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.(In Vitro):MS645 blocks the proliferation of triple-negative breast cancer (TNBC) cells.?MS645 down-regulates proinflammatory cytokines and genes for cell-cycle control and DNA damage repair that are largely unaffected by monovalent BRD inhibition.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetEpigenetic Reader Domain
-
RecptorAndrogen Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2250091-96-2
-
Formula Weight938.05
-
Molecular FormulaC48H54Cl2N10O2S2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 200 mg/mL (213.21 mM)
-
SMILESCc1nnc2[C@H](CC(=O)NCCCCCCCCCCNC(=O)C[C@@H]3N=C(c4c(C)c(C)sc4-n4c(C)nnc34)c3ccc(Cl)cc3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Murakoshi M, et al. Discovery and pharmacological effects of a novel GPR142 antagonist. J Recept Signal Transduct Res. 2017;37(3):290-296.
molnova catalog
related products
-
3-methyl-1,2,3,4-tet...
3-methyl-1,2,3,4-tetrahydroquinazolin-2-one is a inhibitor of BRD4 .
-
JQAD1
JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC?; DC50≤ 31.6 nM); comprises an EP300 inhibitor, A485, joined by a linker to a cereblon E3 ligase ligand.
-
GSK778 hydrochloride
GSK778 hydrochloride hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively.
