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MRT-2359
CAS No. 2803881-11-8
MRT-2359( —— )
Catalog No. M36092 CAS No. 2803881-11-8
MRT-2359 is a potent and orally available GSPT1 reducer with antitumour activity.MRT-2359 inhibits the growth of drug-resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells.MRT-2359 exhibits preferential activity in MYC-driven cell lines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 108 | Get Quote |
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| 5MG | 164 | Get Quote |
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| 10MG | 258 | Get Quote |
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| 25MG | 481 | Get Quote |
|
| 50MG | 686 | Get Quote |
|
| 100MG | 888 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMRT-2359
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NoteResearch use only, not for human use.
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Brief DescriptionMRT-2359 is a potent and orally available GSPT1 reducer with antitumour activity.MRT-2359 inhibits the growth of drug-resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells.MRT-2359 exhibits preferential activity in MYC-driven cell lines.
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DescriptionMRT-2359 is an orally active and potent degrader of GSPT1 (IC50: >30 nM and <300 nM) with anti-tumor activity. MRT-2359 also inhibits the growth of resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells. MRT-2359 exhibits preferential activity in MYC-driven cell lines, such as N- and L-MYC high NSCLC and SCLC patient-derived xenografts (PDXs).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2803881-11-8
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Formula Weight495.38
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Molecular FormulaC22H17F4N3O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (201.87 mM; Ultrasonic )
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SMILESO=C1N(CC=2C1=CC(COC(NC3=CC(OC(F)(F)F)=CC=C3F)=O)=CC2)C4C(=O)NC(=O)CC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gavory G, et al. Development of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for the treatment of lung cancers with MYC-induced translational addiction[J]. Cancer Research, 2023, 83(7_Supplement): 3449-3449.
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