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MRK-623

CAS No. 461449-78-5

MRK-623( MRK623 )

Catalog No. M14556 CAS No. 461449-78-5

MRK-623 is a potent, α2/α3 subunit functionally selectiviie GABAA receptor agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MRK-623
  • Note
    Research use only, not for human use.
  • Brief Description
    MRK-623 is a potent, α2/α3 subunit functionally selectiviie GABAA receptor agonist.
  • Description
    MRK-623 is a potent, α2/α3 subunit functionally selectiviie GABAA receptor agonist.
  • In Vitro
    MRK-623 shows efficacy at human GABAA receptor subtypes expressed in L(tk-) cells measured by whole cell patch-clamp electrophysiology.
  • In Vivo
    MRK-623 (oral gavage; 0.3, 1, and 3 mg/kg; once) shows anxiolytic effects in the rat elevated plus maze assay. Animal Model:RatDosage:0.3, 1, and 3 mg/kg Administration:Oral gavage; 0.3, 1, and 3 mg/kg; once Result:Showed 78% BZ site occupancy at 3 mg/kg, with an ID50 of 0.8 mg/kg.
  • Synonyms
    MRK623
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    GAT
  • Recptor
    GAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    461449-78-5
  • Formula Weight
    348.381
  • Molecular Formula
    C20H17FN4O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    2-(3-(4-fluoro-3-pyridin-3-yl-phenyl)-imidazo(1,2-a)pyrimidin-7-yl)-propan-2-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shinday NM, et al. Neuropsychopharmacology. 2013 May;38(6):1006-14.
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