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MR-L2
CAS No. 2374703-19-0
MR-L2( —— )
Catalog No. M22916 CAS No. 2374703-19-0
MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 196 | In Stock |
|
| 5MG | 335 | In Stock |
|
| 10MG | 500 | In Stock |
|
| 25MG | 806 | In Stock |
|
| 50MG | 1098 | In Stock |
|
| 100MG | 1485 | In Stock |
|
| 500MG | 2961 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMR-L2
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NoteResearch use only, not for human use.
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Brief DescriptionMR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).
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DescriptionMR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).
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In VitroMR-L2 (0.3-10 μM; 1 h) significantly suppresses cAMP elevation and cysts formation in MDCK cells. Cell Viability Assay Cell Line:Madin-Darby Canine Kidney (MDCK) cell line Concentration:0.3, 1, 3 and 10 μM Incubation Time:1 hour Result:Suppressed cAMP elevation but not enhanced cAMP excretion in MDCK cells. Suppressed cysts formation in MDCK cells with an EC50 value of 1.2 μM. Suppressed the number of cysts formation in 3D culture for both unstimulated and vasopressin-treated culture condition while showed no effect on cell viability.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE4
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Research Area——
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Indication——
Chemical Information
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CAS Number2374703-19-0
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Formula Weight441.71
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Molecular FormulaC19H16Cl3FN4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (188.65 mM)
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SMILESClC1=C(F)C=C(C2=NN(CC(NCC3=CC(Cl)=CC(Cl)=C3)=O)C(CC)=N2)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Omar F, et al. Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329.
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