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Home - Products - GPCR/G Protein - Neurokinin Receptor - MLE-4901

MLE-4901

CAS No. 941690-55-7

MLE-4901( MLE4901 | AZD-2624 | AZD2624 | Pavinetant )

Catalog No. M16736 CAS No. 941690-55-7

A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MLE-4901
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia.
  • Description
    A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia; demonstrates drug-like properties with low metabolic turnover rate in vitro and moderate human plasma protein binding.Schizophrenia Phase 2 Discontinued.
  • In Vitro
    Pavinetant (AZD2624) is a potent and selective NK3 receptor antagonist which is developed for the treatment of schizophrenia. Pavinetant exhibits an inhibitory effect on microsomal CYP3A4/5 activities with apparent IC50 values of 7.1 and 19.8 μM for midazolam and testosterone assays, respectively. No time-dependent inactivation of CYP3A4/5 activity by Pavinetant is observed. Pavinetant demonstrates weak to no inhibition of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP2D6.
  • In Vivo
    ——
  • Synonyms
    MLE4901 | AZD-2624 | AZD2624 | Pavinetant
  • Pathway
    GPCR/G Protein
  • Target
    Neurokinin Receptor
  • Recptor
    Neurokinin Receptor
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    941690-55-7
  • Formula Weight
    459.56
  • Molecular Formula
    C26H25N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 50 mg/mL 108.80 mM; H2O : < 0.1 mg/mL
  • SMILES
    O=C(C1=C(NS(=O)(C)=O)C(C2=CC=CC=C2)=NC3=CC=CC=C13)N[C@H](C4=CC=CC=C4)CC
  • Chemical Name
    (S)-3-(methylsulfonamido)-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li Y, et al. Xenobiotica. 2010 Nov;40(11):721-9. 2. Skorupskaite K, et al. Neuroendocrinology. 2017 Apr 5. doi: 10.1159/000473893. 3. Prague JK, et al. Lancet. 2017 May 6;389(10081):1809-1820.
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