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MKC-1

CAS No. 125313-92-0

MKC-1( —— )

Catalog No. M28925 CAS No. 125313-92-0

MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 192 Get Quote
10MG 282 Get Quote
25MG 488 Get Quote
50MG 704 Get Quote
100MG 981 Get Quote
500MG 1971 Get Quote
1G Get Quote Get Quote
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Biological Information

  • Product Name
    MKC-1
  • Note
    Research use only, not for human use.
  • Brief Description
    MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle.
  • Description
    MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle.
  • In Vitro
    ——
  • In Vivo
    MKC-1 (200 mg/kg, orally, daily) significantly increased the median survival time (MST) of mice bearing Caki-1 renal cell xenograft tumors.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    125313-92-0
  • Formula Weight
    400.394
  • Molecular Formula
    C22H16N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 50 mg/mL (124.88 mM)
  • SMILES
    Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3cc(ccc23)[N+]([O-])=O)c2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hyland EE, et al. Unified Access to Pyrimidines and Quinazolines Enabled by N-N Cleaving Carbon Atom Insertion. J Am Chem Soc. 2022 Oct 26;144(42):19258-19264.
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