MK-3281( MK3281 )

Catalog No. M16413 CAS No. 886041-60-7

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Product Name

MK-3281
Note

Research use only, not for human use.
Brief Description

MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase with IC50 of 6 nM; MK-3281 is an equally potent inhibitor of gt 1a (EC50=28 nM), 1b BK (EC50=9 nM), and 3a (EC50=37 nM) replicons.
Description

MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase with IC50 of 6 nM; MK-3281 is an equally potent inhibitor of gt 1a (EC50=28 nM), 1b BK (EC50=9 nM), and 3a (EC50=37 nM) replicons, shows 2 orders of magnitude less active on 2a (EC50=2018 nM) and 2b (EC50=1833 nM) replicons; demonstrates consistent decrease in viremia in vivo using the chimeric mouse model of HCV infection.HCV Infection Phase 1 Discontinued.
In Vitro

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In Vivo

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Synonyms

MK3281
Pathway

Microbiology/Virology
Target

HCV
Recptor

HCV
Research Area

Infection
Indication

HCV Infection

CAS Number

886041-60-7
Formula Weight

475.633
Molecular Formula

C29H37N3O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC2=C(C=C1)C(C3CCCCC3)=C4N2CC(N(CCN(C)C)C)COC5=CC=CC=C45)O
Chemical Name

(7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid

1. Narjes F, et al. J Med Chem. 2011 Jan 13;54(1):289-301.

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