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MDH1-IN-2

CAS No. 2143463-35-6

MDH1-IN-2( —— )

Catalog No. M35631 CAS No. 2143463-35-6

MDH1-IN-2 (7c) is a potent MDH1 inhibitor with an IC50 of 2.27 μM for MDH1 and 27.47 μM for MDH2. MDH1-IN-2 has potential anticancer activity and can be used in the study of diseases related to the immune system.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MDH1-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    MDH1-IN-2 (7c) is a potent MDH1 inhibitor with an IC50 of 2.27 μM for MDH1 and 27.47 μM for MDH2. MDH1-IN-2 has potential anticancer activity and can be used in the study of diseases related to the immune system.
  • Description
    MDH1-IN-2 (Compound 7c) is a potent and selelctive inhibitor of MDH1 with an IC50 of 2.27 μM. MDH1-IN-2 has the potential for the research of cancer diseases.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2143463-35-6
  • Formula Weight
    427.53
  • Molecular Formula
    C25H33NO5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (58.48 mM; Ultrasonic )
  • SMILES
    COC(=O)c1ccc(OC)c(NC(=O)COc2ccc(cc2)C(C)(C)CC(C)(C)C)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Naik R, et al. Methyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism. J Med Chem. 2017;60(20):8631-8646.?
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