Cart
sales@molnova.com
MAP3K14-IN-173
CAS No. 2113617-02-8
MAP3K14-IN-173( MAP3K14 inhibitor )
Catalog No. M13357 CAS No. 2113617-02-8
A novel potent MAP3K14 kinase inhibitor with IC50 of 1.8 nM (NIK autophosphorylation).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1683 | Get Quote |
|
| 50MG | 3402 | Get Quote |
|
| 100MG | 4680 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMAP3K14-IN-173
-
NoteResearch use only, not for human use.
-
Brief DescriptionA novel potent MAP3K14 kinase inhibitor with IC50 of 1.8 nM (NIK autophosphorylation).
-
DescriptionA novel potent MAP3K14 kinase inhibitor with IC50 of 1.8 nM (NIK autophosphorylation); inhibits p-IKKα levels of L363 (NIK translocated multiple myeloma) cells with IC50 of 1.3 nM; exhibits antiproliferative activity on JJN-3 (NIK translocated) multiple myeloma cells (IC50=29 nM).
-
In Vitro——
-
In Vivo——
-
SynonymsMAP3K14 inhibitor
-
PathwayMAPK/ERK Signaling
-
TargetMEK
-
RecptorMEK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2113617-02-8
-
Formula Weight509.614
-
Molecular FormulaC29H31N7O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESN#CC1=CC(C2=NC(NC3=CC(C#N)=C(CCN4CCOCC4)C=C3C)=NC=C2)=CC5=C1NC[C@@]5(CO)C
-
Chemical Name(R)-5-(2-((5-cyano-2-methyl-4-(2-morpholinoethyl)phenyl)amino)pyrimidin-4-yl)-3-(hydroxymethyl)-3-methylindoline-7-carbonitrile
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kargbo RB, et al. ACS Med Chem Lett. 2017 Aug 17;8(9):908-910.
2. Patent WO2017125530 A1, compound example 173.
molnova catalog
related products
-
Refametinib
A potent, non–ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively.
-
MKK7-COV-3
MKK7-COV-3 (MKK7 Covalen inhibitor 3) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 5 nM.
-
Cobimetinib racemate
Cobimetinib racemate is the racemate form of Cobimetinib (GDC-0973, XL518), which is a potent, highly selective inhibitor of MEK1/2.
