High affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.

A potent, first-in-class, oral small-molecule agent for the treatment of inflammatory bowel diseases.

Allomatrine is a natural product from Sophora alopecuroides L. Allomatrine when given i.c.v. may stimulate the descending dynorphinergic neuron resulting in the stimulation of KORs in the spinal cord.