[D-Pro2,D-Trp6,8,Nle10]-Neurokinin B( ——— )

Catalog No. M41434 CAS No. 109212-72-8

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Datasheet

HNMR

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MSDS

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Product Name

[D-Pro2,D-Trp6,8,Nle10]-Neurokinin B
Note

Research use only, not for human use.
Brief Description

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A.
Description

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A.
In Vitro

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In Vivo

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B (1 mg/kg i.v.) significantly reduces Substance P- and Neurokinin B- but not acetylcholine- or Neurokinin A-induced salivation. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B lowers blood pressure in anesthetized rats by 35 to 40%.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

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Research Area

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Indication

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1. H I Jacoby, et al. Differentiation of multiple neurokinin receptors in the guinea pig ileum. Life Sci. 1986 Nov 24;39(21):1995-2003. ?

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