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IL-8 Inhibitor

CAS No. 138559-60-1

IL-8 Inhibitor( ——— )

Catalog No. M41330 CAS No. 138559-60-1

Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    IL-8 Inhibitor
  • Note
    Research use only, not for human use.
  • Brief Description
    Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury.
  • Description
    Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury.
  • In Vitro
    Antileukinate inhibits the binding of human eotaxin to human eosinophils with an IC50 of 8.2 μM.Antileukinate (10-100 μM; 2 hours) significantly suppresses eosinophil chemotaxis to human eotaxin.
  • In Vivo
    Antileukinate (52.63 mg/kg; s.c.) protectes mice against acute pancreatitis and associated lung injury.Antileukinate (5mg/kg; s.c.) inhibits the interaction between murine eotaxin and murine eosinophil.Animal Model:Swiss mice (20-25g)Dosage:52.63 mg/kg Administration:Subcutaneous injectionResult:Reduced pancreatic edema induced by Caerulein (50 μg/kg).
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ———
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    138559-60-1
  • Formula Weight
    1003.2
  • Molecular Formula
    C45H66N18O7S
  • Purity
    >98% (HPLC)
  • Solubility
    ———
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Madhav Bhatia, et al. Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regul Pept. 2007 Jan 10;138(1):40-8.?
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