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α-Conotoxin MI
CAS No. 88217-10-1
α-Conotoxin MI( ——— )
Catalog No. M41036 CAS No. 88217-10-1
α-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Nameα-Conotoxin MI
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NoteResearch use only, not for human use.
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Brief Descriptionα-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs.
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Descriptionα-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs.
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In Vitroα-Conotoxin M I interacts with the α-δ site of the AChR through four hydrophobic residues in its N- and C-terminal loops. Furthermore, the key side chains in α-Conotoxin M I localize in a hydrophobic cluster that interacts with hydrophobic and aromatic residues from both the a and d subunits.
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In Vivo———
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptormAChR; α1β1γδ nAChR
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Research Area———
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Indication———
Chemical Information
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CAS Number88217-10-1
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Formula Weight1497.74
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Molecular FormulaC58H92N22O17S4
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kulak JM, et al. Alpha-conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes. J Neurosci. 1997 Jul 15;17(14):5263-70. ?
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