R9

Research use only, not for human use.

(Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.

(Arg)9 (Nona-L-arginine;Peptide R9) is a cell-penetrating peptide,and exhibits neuroprotective activity(IC50 of 0.78 μM, in the glutamic acid model).

(Arg)9 (Nona-L-arginine; 5-10 μM) provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC50=0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC50=0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC50=6 μM).

(Arg)9 (Nona-L-arginine; 1μM/kg (600 μL); i.v.; once, for 30min; male Sprague–Dawley ratspermanent middle cerebral artery stroke model) shows neuroprotective effects and reduces infarct volume.Animal Model:Male Sprague–Dawley rats (270 to 320?g) permanent middle cerebral artery stroke model Dosage:1 μM/kg (600? μL) Administration:Intravenous injection; once, over 5 minutes Result:Reduced significantiy 20% in infarct volume.

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Others

Other Targets

neuroprotection

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143413-47-2

1423.69

C54H110N36O10

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years