Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries.

N-Acetyl-L-alanine is a substrate for Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit Myelin basic protein GTP-binding nuclear protein Ran Tropomyosin alpha 4 chain HIV-1 Rev binding protein 2 Xaa-Pro dipeptidase Thymosin beta-10 Actin-like protein 3 Alanine aminotransferase Serine/threonine protein phosphatase PP1-beta catalytic subunit 10 kDa heat shock protein (mitochondrial) Calmodulin and Beta-1-syntrophin.

N1-Acetylspermidine hydrochloride, an acetyl derivative of spermidine, serves as a substrate for polyamine oxidase and selectively elevates its levels in human colorectal adenocarcinomas.