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Cortistatin-29 (rat)

CAS No. 1815618-17-7

Cortistatin-29 (rat)( ——— )

Catalog No. M40792 CAS No. 1815618-17-7

Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Cortistatin-29 (rat)
  • Note
    Research use only, not for human use.
  • Brief Description
    Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.
  • Description
    Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.
  • In Vitro
    ———
  • In Vivo
    Animal Model:20-24 g body weight, 8-12 weeks-old mice Dosage:1 μg in 20 μL for s.c.; 2 μg in 200 μL for i.p.; 20 ng in 10 μL for i.t.Administration:Every other day for 12 days Result:Ameliorated hyperalgesia and allodynia, regulated the nerve damageinduced hypersensitization of primary nociceptors, inhibited neuroinflammatory responses, and enhanced the production of neurotrophic factors both at the peripheral and central levels.
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    SSTR1: 2.8 nM (IC50), SSTR2: 7.1 nM (IC50), SSTR3: 0.2 nM (IC50), SSTR4: 3.0 nM (IC50), SSTR5: 13.7 nM (IC50)]
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    1815618-17-7
  • Formula Weight
    3540.09
  • Molecular Formula
    C161H240N46O41S2
  • Purity
    >98% (HPLC)
  • Solubility
    ———
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Falo CP, et al. The Neuropeptide Cortistatin Alleviates Neuropathic Pain in Experimental Models of Peripheral Nerve Injury. Pharmaceutics. 2021 Jun 24;13(7):947.?
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