Cart
sales@molnova.com
Home - Products - Others - Other Targets - 1H-Purine-2,6-dione

1H-Purine-2,6-dione

CAS No. 2253744-57-7

1H-Purine-2,6-dione( ——— )

Catalog No. M39452 CAS No. 2253744-57-7

TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 453 Get Quote
25MG Get Quote Get Quote
50MG Get Quote Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    1H-Purine-2,6-dione
  • Note
    Research use only, not for human use.
  • Brief Description
    TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.
  • Description
    TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1.
  • In Vitro
    TH5427 hydrochloride inhibits progestin-dependent nuclear ATP synthesis in breast cancer cells. TH5427 hydrochloride significantly disrupted EGFR and MMTV-luc expression following progestin stimulation. TH5427 hydrochloride abrogates the progestin-dependent proliferation response in T47DWT cells.
  • In Vivo
    ———
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ———
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    2253744-57-7
  • Formula Weight
    527.79
  • Molecular Formula
    C20H21Cl3N8O3
  • Purity
    >98% (HPLC)
  • Solubility
    ———
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells published correction appears in Nat Commun. 2019 Nov 1;10(1):5050. Nat Commun. 2018;9(1):250. Published 2018 Jan 17.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • H-Val-Pro-Pro-OH TFA...

    H-Val-Pro-Pro-OH(TFA), a proline peptide derivative from milk, is an ACE inhibitor with IC50 of 9 M.

  • Fumarate hydratase-I...

    Fumarate hydratase-IN-1 is a cell-permeable fumarate hydratase inhibitor with antiproliferative activity and can be used to study cellular activity.

  • 1-Hexanol

    1-Hexanol is a natural product.1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties.

Sign In Join Free