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JHU-083
CAS No. 1998725-11-3
JHU-083( ——— )
Catalog No. M39444 CAS No. 1998725-11-3
JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 446 | In Stock |
|
| 10MG | 730 | In Stock |
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| 25MG | 1387 | In Stock |
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| 50MG | 1748 | In Stock |
|
| 100MG | 2306 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJHU-083
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NoteResearch use only, not for human use.
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Brief DescriptionJHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals.
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DescriptionJHU-083 is a selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells. JHU-083 also experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals.
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In Vitro———
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In VivoAnimal Model:Male 7-to 8-week-old C57BL/6J (C57) mice (25-30?g) with chronic social defeat stress (CSDS)Dosage:1.82?mg/kg Administration:PO; every other day for 12 days Result:Ameliorated social avoidance behavior and anhedonia-like behavior induced by CSDS.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorGlutamine
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Research Area———
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Indication———
Chemical Information
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CAS Number1998725-11-3
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Formula Weight312.37
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Molecular FormulaC14H24N4O4
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Purity>98% (HPLC)
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SolubilityEthanol : 133.33 mg/mL (426.85 mM; ultraphonic) DMSO : 100 mg/mL (320.14 mM; ultraphonic; ) H2O : 50 mg/mL (160.07 mM; ultraphonic)
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SMILES[C@H](NC([C@H](CC(C)C)N)=O)(CCC(C=[N+]=[N-])=O)C(OCC)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694.?
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