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Nigranoic acid

CAS No. 39111-07-4

Nigranoic acid( ——— )

Catalog No. M39372 CAS No. 39111-07-4

Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Nigranoic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model.
  • Description
    Nigranoic acid is a natural product,and inhibits HIV-1 reverse transcriptase.
  • In Vitro
    ———
  • In Vivo
    Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation. Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.Animal Model:Sprague–Dawley rats (200-300 g), ischemia–reperfusion model Dosage:1 mg/kg Administration:Intragastric; 6 hours and 2 hours before brain ischemia Result:Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    HIV-1 reverse transcriptase
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    39111-07-4
  • Formula Weight
    470.68
  • Molecular Formula
    C30H46O4
  • Purity
    >98% (HPLC)
  • Solubility
    ———
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sun HD, et al. Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase. J Nat Prod. 1996 May;59(5):525-7.?
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