Hinesol

Research use only, not for human use.

(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer.

Hinesol is a unique sesquiterpenoid isolated from Atractylodes lancea rhizome. Hinesol has been found to induce apoptosis through the JNK signaling pathway in HL-60 cells.

(-)-Hinesol (0-25 μg/ml; 24, 48 h) shows antiproliferative activity of the A549 and NCI-H1299 cells in a dose- and time-dependent manner.(-)-Hinesol (0, 2, 8 μg/ml; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase with increases the expression of Bax and decreases the expression of Bcl-2 and cyclin D1.(-)-Hinesol (0, 2, 8 μg/ml; 24 h) decreases the expression of phosphor-ERK1/2, phosphor-MEK1/2, phosphor-IκBα and -p65 level, and shows no change forthe total protein levels of IκBα and p65 in A549 cells.Cell Proliferation Assay Cell Line:A549, NCI-H1299 cells Concentration:0-25 μg/ml Incubation Time:24, 48 h Result:Inhibited the proliferation of the A549 and NCI-H1299 cells in a dose- and time-dependent manner.Apoptosis Analysis Cell Line:A549 cells Concentration:0, 2, 8 μg/ml Incubation Time:24 h Result:Induced apoptosis with the apoptotic cells was increased to 21.2?±?0.96% and 36?±?1.04% after treatment with hinesol at 2 and 8?μg/mL, respectively.Western Blot Analysis Cell Line:A549 cells Concentration:0, 2, 8 μg/ml Incubation Time:24 h Result:Increased the protein expression of Bax and decreased the expression of Bcl-2.Cell Cycle Analysis Cell Line:A549 cells Concentration:0, 2, 8 μg/ml Incubation Time:24 h Result:Showed concentration-dependent increase in the percentage of cell in the G0/G1 phase, and a decrease of the percentage in G2/M phase.

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Others

Other Targets

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23811-08-7

222.37

C15H26O

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years