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Aloenin aglycone
CAS No. 59163-53-0
Aloenin aglycone( ——— )
Catalog No. M38593 CAS No. 59163-53-0
Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC50: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAloenin aglycone
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NoteResearch use only, not for human use.
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Brief DescriptionAloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC50: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα.
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DescriptionAloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC50: 18.7 μM).
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In Vitro———
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In Vivo———
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Synonyms———
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PathwayOthers
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TargetOther Targets
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Recptorintercellular adhesion molecule-1 (ICAM-1)
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Research Area———
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Indication———
Chemical Information
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CAS Number59163-53-0
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Formula Weight248.23
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Molecular FormulaC13H12O5
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sun Y N, et al. Isolation and identification of chromone and pyrone constituents from Aloe and their anti-inflammatory activitiesJ. Journal of Functional Foods, 2016, 21: 232-239.
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