Rhaponticin(Rhaponiticin) can alleviate liver steatosis and improve blood glucose and lipid profiles in KK/Ay diabetic mice, indicates that rhaponticin has a noticeable antidiabetic effect.

Potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.

Bruceantin is a natural product isolated from Brucea antidysenterica. Bruceantin has antitumor activity against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice.