E-I-L-E-V-P-S-T

CHMFL-KIT-033 is a potent and selective inhibitor of the c-KIT T670I mutant (IC50: 0.045 μM) for gastrointestinal stromal tumors (GISTs).

5-Hydroxymethyluracil is an oxidation damage product derived from thymine or 5-methylcytosine. It is a product of thymine dioxygenase. Additional deamination products such as 5-hydroxymethyluracil are formed when cells are under oxidative stress that is induced either by oxidizing agents or by mitochondrial dysfunction.