3,3-Dimethyl-1-butanol

Research use only, not for human use.

3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-Dimethyl-1-butanol inhibits the signaling pathway of p65 NF-κB and TGF-β1/Smad3. 3,3-Dimethyl-1-butanol has potential applications in cardiovascular disease (CVD).

3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO).

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Animal Model:C57BL6/J male mice (8-10 weeks old) with heart failure.Dosage:1% DMB soluble in water.Administration:Oral gavage; 6 weeks.Result:Reduced the plasma trimethylamine N-oxide (TMAO) levels, the cross-sectional area of LV cardiomyocytes, and the area of LV interstitial fibrosis.Decreased the expression of ANP, BNP, β-MHC, collagen Iα, collagen III and CTGF. Inhibited TNF-α, IL-6, IL-1β, p65, TGF-β and Smad3 expression. Animal Model:Male and female ICR mice (8-weeks old).Dosage:0.2% and 1.0% DMB soluble in water.Administration:Oral gavage; 21 d.Result:Showed insignificantly effect on body weight, water intake, food intake, sexual preference, anxiety, depression and memory formation. Weakened the social dominance of mice. Animal Model:Pregnant Sprague-Dawley rats.Dosage:1.0% DMB soluble in water.Administration:Oral gavage; gestation period and suckling period.Result:Increased kidney weight, plasma trimethylamine (TMA) level and acetic acid, reduced diastolic.

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Others

Other Targets

NF-κB

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624-95-3

102.17

C6H14O

>98% (HPLC)

DMSO : 100 mg/mL (978.76 mM ) H2O : 9.09 mg/mL (88.97 mM)

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(-20℃)

With Ice Pack

≥ 2 years