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PNU-282987

CAS No. 123464-89-1

PNU-282987 ( ——— )

Catalog No. M38006 CAS No. 123464-89-1

PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 67 In Stock
5MG 38 In Stock
10MG 61 In Stock
25MG 123 In Stock
50MG 220 In Stock
100MG 314 In Stock
200MG 458 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    PNU-282987
  • Note
    Research use only, not for human use.
  • Brief Description
    PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems.
  • Description
    PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM.
  • In Vitro
    PNU-282987 (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a Ki of 27 nM.PNU-282987 has α7 nAChR agonist activity with an EC50 of 154 nM.PNU-282987 also has inhibition for the 5-HT3 receptor with an IC50 value of 4541nM.
  • In Vivo
    PNU-282987 (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit.PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner.Animal Model:Rats Dosage:1, 3 mg/kg Administration:i.v.Result:Significantly reversed amphetamine-induced gating deficit.
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    5-HT Receptor
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    123464-89-1
  • Formula Weight
    301.21
  • Molecular Formula
    C14H18Cl2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ?H2O : 50 mg/mL (166.00 mM; ultraphonic) DMSO : 10 mg/mL (33.20 mM; ultraphonic (<60°C)
  • SMILES
    Cl.C1CN2CCC1[C@H](C2)NC(=O)c1ccc(cc1)Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Alice L Bodnar, et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem?
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