Fagomine( —— )

Catalog No. M37948 CAS No. 53185-12-9

Fagomine (D-Fagomine) is a mild glycosidase inhibitor, an analog of 1-deoxynojirimycin (DNJ) with hypoglycemic activity, and Fagomine reduces intracellular reactive oxygen species (ROS) production and malondialdehyde (MDA) levels.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Fagomine
Note

Research use only, not for human use.
Brief Description

Fagomine (D-Fagomine) is a mild glycosidase inhibitor, an analog of 1-deoxynojirimycin (DNJ) with hypoglycemic activity, and Fagomine reduces intracellular reactive oxygen species (ROS) production and malondialdehyde (MDA) levels.
Description

Fagomine is a mild glycosidase inhibitor. The Ki of the iminosugar Fagomine is 4.8 μM, 39 μM, and 70 μM for Amyloglucosidase (A.niger), β-Glucosidase (bovine), and Isomaltase (yeast), respectively.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Immunology/Inflammation
Target

ROS
Recptor

ROS | glycosidase
Research Area

——
Indication

——

Chemical Information

CAS Number

53185-12-9
Formula Weight

147.17
Molecular Formula

C6H13NO3
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : ≥ 36 mg/mL (244.62 mM)
SMILES

OC[C@H]1NCC[C@@H](O)[C@@H]1O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Mena-Barragán T, et al. Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp2-iminosugar conjugates againstglycosidases: A structure-activity relationship study in Gaucher fibroblasts. Eur J Med Chem. 2015 Aug 31. pii: S0223-5234(15)30222-1.?

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