Paeonoside

Research use only, not for human use.

Paeonoside, found in P. suffruticosa, is biologically active and can promote wound healing and migration during osteoblast differentiation.

Paeonoside is a bioactive compound identified in P. suffruticosa that promotes wound healing and migration in osteoblast differentiation. Paeonoside has also been reported to have some antidiabetic activity and may prevent sepsis-induced lethality.

Paeonoside (PASI) (0.1-100 μM, 24 h) has no cytotoxic effect on pro-osteoblasts of MC3T3-E1 cells. Paeonoside (PASI) (1-30 μM, 24 h) can significantly restore wound areas and promote cell migration in a dose-dependent manner during the induction of preosteoblast of MC3T3-E1 cells differentiation using osteogenic supplement (OS) medium. In parallel, PASI promotes alkaline phosphatase (ALP) staining and its activity in a dose-dependent manner.Western Blot Analysis Cell Line:Pro-osteoblasts of MC3T3-E1 cells Concentration:1-10 μM Incubation Time:24 h Result:Increased the expression of BMP2 and Wnt3a, stimulated Smad1/5/8 phosphorylation, GSK3β phosphorylation and β-linked protein expression as well as upregulated RUNX2 expression.

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Others

Other Targets

Others

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20309-70-0

328.31

C15H20O8

>98% (HPLC)

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O(C1=C(C(C)=O)C=CC(OC)=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O

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(-20℃)

With Ice Pack

≥ 2 years