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5-HT3 antagonist 5

CAS No. 901599-43-7

5-HT3 antagonist 5( —— )

Catalog No. M37682 CAS No. 901599-43-7

5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound that acts as a 5-HT3 receptor antagonist, counteracting 5-HT3 agonist and 2-methyl-5-HT, and demonstrating an anti-depressant effect in mice .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 46 In Stock
5MG 42 In Stock
10MG 65 In Stock
25MG 131 In Stock
50MG 210 In Stock
100MG 300 In Stock
200MG 384 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    5-HT3 antagonist 5
  • Note
    Research use only, not for human use.
  • Brief Description
    5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound that acts as a 5-HT3 receptor antagonist, counteracting 5-HT3 agonist and 2-methyl-5-HT, and demonstrating an anti-depressant effect in mice .
  • Description
    5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice.
  • In Vitro
    5-HT3 antagonist 5 (compound 4c) exhibits 5-HT3 receptor antagonisms in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT3 agonist, 2-methyl-5-HT, with pA2 value of 5.
  • In Vivo
    5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) decreases the duration of immobility and shows anti-depressant effect in FST mice.Animal Model:Swiss albino mice (23 ± 2 g) Dosage:1 mg/kg Administration: Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration Result:Reduced the duration of immobility as compared to the vehicle-treated (control) group.Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    901599-43-7
  • Formula Weight
    279.29
  • Molecular Formula
    C16H13N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20.83 mg/mL (74.58 mM; Ultrasonic (<60°C)
  • SMILES
    COc1ccc(NC(=O)c2cnc3ccccc3n2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mahesh R, et al. Design, synthesis and structure-activity relationship of novel quinoxalin-2-carboxamides as 5-HT3 receptor antagonists for the management of depression. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6773-6. ?
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