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RET-IN-3

CAS No. 2414374-53-9

RET-IN-3( —— )

Catalog No. M37651 CAS No. 2414374-53-9

RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 168 In Stock
5MG 152 In Stock
10MG 240 In Stock
25MG 451 In Stock
50MG 697 In Stock
100MG 1070 In Stock
200MG 1442 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    RET-IN-3
  • Note
    Research use only, not for human use.
  • Brief Description
    RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.
  • Description
    RET-IN-3 (compound 34) is a selective RETV804M kinase inhibitor, with an IC50 of 19 nM.
  • In Vitro
    RET-IN-3 exhibits 16 and 410 fold selectivity compared to wt-RET and KDR, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Tyrosine Kinase
  • Target
    c-RET
  • Recptor
    c-RET
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2414374-53-9
  • Formula Weight
    339.39
  • Molecular Formula
    C18H21N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (294.65 mM; Ultrasonic )
  • SMILES
    CN(C)CCCNc1ccn2ncc(-c3ccc4OCOc4c3)c2n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.?
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