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HM43239 B
CAS No. 2294874-49-8
HM43239 B( —— )
Catalog No. M37626 CAS No. 2294874-49-8
HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 97 | Get Quote |
|
| 5MG | 147 | Get Quote |
|
| 10MG | 226 | Get Quote |
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| 25MG | 428 | Get Quote |
|
| 50MG | 612 | Get Quote |
|
| 100MG | 835 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameHM43239 B
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NoteResearch use only, not for human use.
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Brief DescriptionHM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively.
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DescriptionTuspetinib (HM43239) is an orally active and selective FLT3 inhibitor with IC50s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. Tuspetinib inhibits the kinase activity of FLT3 as a reversible type I inhibitor and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib inhibits the proliferation and induces the apoptosis of leukemic cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetFLT
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RecptorFLT
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Research Area——
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Indication——
Chemical Information
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CAS Number2294874-49-8
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Formula Weight501.07
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Molecular FormulaC29H33ClN6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (249.47 mM; Ultrasonic )
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SMILESC[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Miyoung Lee, et.al. Abstract 804: Antitumor activity of the potent and novel FLT3 inhibitor HM43239 in acute myeloid leukemia. Cancer Res July 1 2018 (78) (13 Supplement) 804.
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HM43239
HM43239 is a selective FLT3 inhibitor (IC50s: 1.1 nM for FLT3 WT, 1.8 nM for FLT3 ITD, and 1.0 nM for FLT3 D835Y kinases, respectively).
