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PDL-1 cpd 10
CAS No. 2767424-13-3
PDL-1 cpd 10( —— )
Catalog No. M37623 CAS No. 2767424-13-3
PDL-1 cpd 10 is a novel small molecule PD-L1 inhititor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 123 | In Stock |
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| 5MG | 112 | In Stock |
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| 10MG | 180 | In Stock |
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| 25MG | 376 | In Stock |
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| 50MG | 546 | In Stock |
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| 100MG | 761 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePDL-1 cpd 10
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NoteResearch use only, not for human use.
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Brief DescriptionPDL-1 cpd 10 is a novel small molecule PD-L1 inhititor.
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DescriptionPD-L1-IN-1 is a potent PD-L1 inhibitor with an IC50 of 115 nM. PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells (PC9 and HCC827 cells) and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter. PD-L1-IN-1 significantly increased interferon γ release and apoptotic induction of cancer cells, with low cytotoxicity in healthy cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetPD-1/PD-L1
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RecptorPD-1/PD-L1
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Research Area——
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Indication——
Chemical Information
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CAS Number2767424-13-3
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Formula Weight377.44
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Molecular FormulaC21H23N5O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (331.18 mM; Ultrasonic (<60°C)
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SMILESCC1=C(C=CC=C1COC=2N=C(NCCNC(C)=O)N=CN2)C3=CC=CC=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Russomanno P, et al. Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors. J Med Chem. 2021;64(21):16020-16045. ?
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