ALC-0315( —— )

Catalog No. M37618 CAS No. 2036272-55-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

ALC-0315
Note

Research use only, not for human use.
Brief Description

ALC-0315 is an ionizable amino lipid that has been used in combination with other lipids to form lipid nanoparticles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine
Description

ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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CAS Number

2036272-55-4
Formula Weight

766.27
Molecular Formula

C48H95NO5
Purity

>98% (HPLC)
Solubility

In Vitro:?Ethanol : 100 mg/mL (130.50 mM; Ultrasonic) DMSO : 50 mg/mL (65.25 mM; Ultrasonic )
SMILES

CCCCCCCCC(CCCCCC)C(=O)OCCCCCCN(CCCCO)CCCCCCOC(=O)C(CCCCCC)CCCCCCCC
Chemical Name

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1. Moghimi SM. Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines. Mol Ther. 2021;29(3):898-900.?

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