PF-03049423 B

Research use only, not for human use.

PF-03049423 is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of approximately 0.2 nM for rat and human thrombomodulin.

PF-03049423 (Compound PF-5) free base is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 free base can be used for the research of acute ischaemic stroke.

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PF-03049423 (Compound PF-5) (1-10 mg/kg; s.c.; b.i.d. for 7 days) promotes functional recovery in a rat model of severe stroke induced by permanent middle cerebral artery occlusion.PF-03049423 (1.0 mg/kg b.i.d. or 0.6 mg/kg q.d. for 7 days) improves poststroke sensory–motor behavioral outcome even when the treatment is initiated 24-72 hours after occlusion.Animal Model:Male Sprague-Dawley rats, middle cerebral artery occlusion (MCA-o) model Dosage:0.1, 1, or 10 mg/kg Administration:Subcutaneous injection, b.i.d. for 7 daysResult:Improved functional recovery at 1 mg/kg and 10 mg/kg.

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Others

Other Targets

Others

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954138-07-9

468.55

C24H32N6O4

>98% (HPLC)

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C(COCCC)N1C=2C(N=C(C1=O)N3CCN(CCO)CC3)=CN=C(C2)C=4C=CC(OC)=NC4

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(-20℃)

With Ice Pack

≥ 2 years