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ML266

CAS No. 1462267-08-8

ML266( —— )

Catalog No. M37610 CAS No. 1462267-08-8

ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 μM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 117 In Stock
2MG 65 In Stock
5MG 107 In Stock
10MG 169 In Stock
25MG 344 In Stock
50MG 463 In Stock
100MG 674 In Stock
200MG Get Quote In Stock
500MG 1414 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    ML266
  • Note
    Research use only, not for human use.
  • Brief Description
    ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 μM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function.
  • Description
    ML266 is glucocerebrosidase (GCase) molecule chaperone with IC50 of 2.5 μM. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the activity of GCase. ML266 dose not inhibit the GCase enzyme’s action. ML266 has the potential for the research of gaucher disease.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Glucokinase
  • Recptor
    Glucokinase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1462267-08-8
  • Formula Weight
    496.35
  • Molecular Formula
    C24H22BrN3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (251.84 mM; Ultrasonic )
  • SMILES
    CN(C(=O)CNC(=O)c1ccccc1OCC(=O)Nc1ccc(Br)cc1)c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rogers S, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7].?
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