Endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrenal chromaffin cells in vivo. Corresponds to amino acids 1 - 20 of proadrenomedullin. Antihypertensive.

Thymidine-5'-monophosphate (TMP) is found in DNA. In mammalian cells thymidine deprivation induces chromosome aberrations such as chromatid breaks chromatid interchanges and chromosome fragmentation.

Pannexin - 1 Fragment (4515)