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NT-0796

CAS No. 2272917-13-0

NT-0796( —— )

Catalog No. M37302 CAS No. 2272917-13-0

NT-0796 is a brain-permeable, potent, and selective inhibitor of the inflammasome NLRP3, inhibiting NLRP3 activation.NT-0796 is a potential NDT-19795 delivery vector.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NT-0796
  • Note
    Research use only, not for human use.
  • Brief Description
    NT-0796 is a brain-permeable, potent, and selective inhibitor of the inflammasome NLRP3, inhibiting NLRP3 activation.NT-0796 is a potential NDT-19795 delivery vector.
  • Description
    NT-0796 is a selective and CNS-penetrant NLRP3 inflammasome inhibitor with an IC50 of 0.32 nM in PBMC assay. NT-0796 is an isopropyl ester that undergoes intracellular conversion to NDT-19795, the carboxylic acid active species. NT-0796 has the potential for neuroinflammatory diseases research.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    NF-κB
  • Target
    NOD
  • Recptor
    NOD
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2272917-13-0
  • Formula Weight
    409.48
  • Molecular Formula
    C23H27N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N(C(O[C@H](CC=1N=CC=CN1)C(OC(C)C)=O)=O)C2=C3C(=CC4=C2CCC4)CCC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. David Harrison, et al. Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders. J Med Chem. 2023 Oct 24.?
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