Bintrafusp alfa( —— )

Catalog No. M37267 CAS No. 1918149-01-5

Bintrafusp alfa (M7824) is a bifunctional fusion protein consisting of the extracellular structural domain of TGF-βRII (a TGF-β “trap”) fused to a monoclonal antibody against human immunoglobulin G1 fused to programmed death ligand 1 (PD-L1).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Bintrafusp alfa
Note

Research use only, not for human use.
Brief Description

Bintrafusp alfa (M7824) is a bifunctional fusion protein consisting of the extracellular structural domain of TGF-βRII (a TGF-β “trap”) fused to a monoclonal antibody against human immunoglobulin G1 fused to programmed death ligand 1 (PD-L1).
Description

Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

TGF-beta/Smad
Research Area

——
Indication

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Chemical Information

CAS Number

1918149-01-5
Formula Weight
Molecular Formula

——
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

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Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Strauss J, et, al. Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies. J Immunother Cancer. 2020 Dec;8(2):e001395.?

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