TIE-2/VEGFR-2 kinase-IN-5( —— )

Catalog No. M37252 CAS No. 1014407-83-0

TIE-2/VEGFR-2 kinase-IN-5 (TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor) is a potent agent with anti-angiogenic activity, commonly used in biomedical research focused on angiogenesis.

Purity : >98% (HPLC)

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Biological Information

Product Name

TIE-2/VEGFR-2 kinase-IN-5
Note

Research use only, not for human use.
Brief Description

TIE-2/VEGFR-2 kinase-IN-5 (TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor) is a potent agent with anti-angiogenic activity, commonly used in biomedical research focused on angiogenesis.
Description

TIE-2/VEGFR-2 kinase-IN-5 is an anti-angiogenic agent. TIE-2/VEGFR-2 kinase-IN-5 also is a potent TIE-2 and VEGFR-2 tyrosine kinase inhibitor with pIC50 values of 7.78 nM and 8.11 nM, respectively. TIE-2/VEGFR-2 kinase-IN-5 can be used for the research of angiogenesis.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

VEGFR
Recptor

VEGFR | Tie-2
Research Area

——
Indication

——

Chemical Information

CAS Number

1014407-83-0
Formula Weight

481.35
Molecular Formula

C21H13F6N5O2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NC=1C=CC(=CC1)C2=COC3=NC=NC(N)=C32)NC=4C=C(C=C(C4)C(F)(F)F)C(F)(F)F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Miyazaki Y, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1773-8. ?

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