IACS-52825( —— )

Catalog No. M37232 CAS No. 2640376-72-1

IACS-52825 is a selective and potent dual leucine zipper kinase (DLK) inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model for the study of neurological disorders.

Purity : >98% (HPLC)

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Biological Information

Product Name

IACS-52825
Note

Research use only, not for human use.
Brief Description

IACS-52825 is a selective and potent dual leucine zipper kinase (DLK) inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model for the study of neurological disorders.
Description

IACS-52825 is a potent and selective DLK inhibitor with Kd of 1.3 nM, useful for the study of chemotherapy-induced peripheral neuropathy.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

DNA Alkylation
Research Area

——
Indication

——

Chemical Information

CAS Number

2640376-72-1
Formula Weight

426.29
Molecular Formula

C16H13F7N4O2
Purity

>98% (HPLC)
Solubility

——
SMILES

[C@@H](C(F)(F)F)(O)C=1N(C23CC(F)(C2)C3)C=C(N1)C=4C=C(OC(F)(F)F)C(N)=NC4
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kang Le, et al. Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy. J Med Chem. 2023 Jul 27;66(14):9954-9971. ?

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