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BTM-3528
CAS No. 2054998-45-5
BTM-3528( —— )
Catalog No. M37219 CAS No. 2054998-45-5
BTM-3528 is an activator of the mitochondrial protease OMA1 with anticancer activity.BTM-3528 activates the ISR via the mitochondrial protease OMA1, inducing OMA1-dependent cleavage of DELE1 and OPA1 and mitochondrial fragmentation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1036 | In Stock |
|
| 10MG | 1226 | In Stock |
|
| 25MG | 1587 | In Stock |
|
| 50MG | 2027 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBTM-3528
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NoteResearch use only, not for human use.
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Brief DescriptionBTM-3528 is an activator of the mitochondrial protease OMA1 with anticancer activity.BTM-3528 activates the ISR via the mitochondrial protease OMA1, inducing OMA1-dependent cleavage of DELE1 and OPA1 and mitochondrial fragmentation.
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DescriptionBTM-3528 is an activator of the mitochondrial protease OMA1 and mediates excessive activation of the mitochondrial integrated stress response (ISR). BTM-3528 stimulates OMA1-dependent DELE1 and OPA1 cleavage and mitochondrial fragmentation. BTM-3528 activates eIF2α kinase HRI, inducing cell growth arrest and apoptosis. BTM-3528 has anticancer activity against multiple DLBCL cell lines and has in vivo inhibitory potency in a mouse model xenografted with human DLBCL SU-DHL-10 cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number2054998-45-5
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Formula Weight521.55
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Molecular FormulaC24H19F4N3O2S2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)C1=C(C=2C=CC=C(F)C2)C(=NN1C3=NC(=C(S3)SC(C)C)C=4C=CC(=CC4)C(F)(F)F)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Schwarzer A, et al. Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1. Mol Cancer Ther. 2023 Aug 30.. .?
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